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CDC Guideline for Prescribing Opioids for Chronic Pain


Dangerous Drug Interactions: Please consult your health care provider before using prescription pain medications with other substances.

Did you know that according to the CDC, about one half of deaths from prescription pain medications involve the use of at least one other drug? Mixing opioids with other substances can cause dangerous side effects, including breathing trouble, coma and even permanent brain damage or death. If you are taking prescription pain medications, do NOT take the following without first talking to your health care provider:
- Alcohol (including beer, wine, and liquor)
- Antihistamines (including allergy medications such as Benadryl)
- Cough medicine/cough syrup
- Barbiturates and benzodiazepines (often used as sleeping pills and sedatives, such as Ambien, Xanax and Valium)
- General anesthetics (often used for surgery)

For more information on safer, more effective pain management for chronic pain, visit CDC Guideline for Prescribing Opioids for Chronic Pain | Drug Overdose | CDC Injury Center | Drug Overdose | CDC Injury Center

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